Peace Essay Example for Free

Peace Essay Peace is a state of harmony characterized by the lack of violence, conflict behaviors and the freedom from fear of violence. Commonly understood as the absence of hostility, peace also suggests the existence of healthy or newly healed interpersonal or international relationships, prosperity in matters of social or economic welfare, the establishment of equality, and a working political order that serves the true interests of all. Etymology [edit] From the Latin pax, meaning freedom from civil disorder, the English word came into use in various personal greetings from c. 300 as a translation of the Hebrew shalom. Such a translation is, however, imprecise, as shalom, which is also cognate with the Arabic salaam, has multiple other meanings in addition to peace, including justice, good health, safety, well-being, prosperity, equity, security, good fortune, and friendliness. [citation needed] At a personal level, peaceful behaviors are kind, considerate, respectful, just, and tolerant of others beliefs and behaviors — tending to manifest goodwill. This latter understanding of peace can also pertain to an individuals introspective sense or concept of her/himself, as in being at peace in ones own mind, as found in European references from c. 1200. The early English term is also used in the sense of quiet, reflecting calm, serene, and meditative approaches to family or group relationships that avoid quarreling and seek tranquility — an absence of disturbance or agitation. In many languages the word for peace is also used a greeting or a farewell, for example the Hawaiian word Aloha, as well as the Arabic word salaam. In English the word peace is occasionally used as a farewell, especially for the dead, as in the phrase Rest In Peace. Buddhists believe that peace can be attained once all suffering ends. They regard all suffering as stemming from cravings (in the extreme, greed), aversions (fears), or delusions. To eliminate such suffering and achieve ersonal peace, followers in the path of the Buddha adhere to a set of teachings called the Four Noble Truths — a central tenet in Buddhist philosophy. Islam means submission. Muslim, etymologically directly related to salaam and the name Islam, means a person who submits to Allah in salaam. [citation needed] Submission to Allah is based on humility. An attitude of humility within ones own self cannot be accomplished without total rejection of violence, and a personal attitude and alignment toward pe ace.

Samsung SWOT and PESTEL Analysis

Samsung SWOT and PESTEL Analysis SWOT ANALYSIS Definition This is part of a companys strategic planning process that connects the companys objectives and strategies to tactics and actions carried out by employees. Often SWOT is part of a companys strategic planning process that connects its objectives and strategies to actions and tactics carried out by employees.   To better decide what changes to be made in a company and know where it stands on four key strategic areas it has to use a SWOT analysis. SWOT Basics Strength, Weakness, Opportunity and Threats (SWOT) is an acronym that identifies the four critical elements of this analysis.   Strengths usually explain in detail an analysis of the companys advantages over its competitors. Weaknesses evaluate areas in which the company is at a competitive disadvantage and has a possibility of failure. Opportunities are untapped markets or business developments that the company could venture in and make profit. Threats transverse the external environment that could affect the company, an example being technological, environmental and regulatory factors. Strengths and Weaknesses The main reason for using the SWOT analysis is so as to be able to evaluate and assess a companys strengths and weaknesses. This helps the company understand its main market advantages and areas that competitors could take advantage of.   Companies take advantage of its strengths by using them as marketing messages so as to differentiate them from their competitors.   By understanding their weaknesses companies can decide what areas need improvement and what areas are deeply rooted in the nature of its business. Opportunities By exploring untapped opportunities company leaders are able to consider ways to grow. Any strong company has to look for ways to improve and elevate its growth curve because without growth means failure and lack of utilization of opportunities, therefore, giving an advantage to the competitors. Opportunities are areas that could create more sales and profits to the company, and these can be the inclusion of new and emerging markets, new business and product developments and lastly strategic business partnerships. Threats Though this is not fun at all, companies always need to have an idea of what external threats they may encounter so they can always be prepared and avoid being caught unawares.   Government regulation changes may affect the level of competition or costs companies face. Ways in which a company gets access and uses natural resources can be affected by environmental or conditional changes.   Companies that do not incorporate new technologies are always affected negatively. (Hill and   Westbrook (1997). WHAT IS PESTEL   ANALYSIS AND WHY IT’S USEFUL? So as to be able to achieve maximum results and get to its optimum performance a company has to consider some factors. The Pestel analysis explains these factors in six categories.   POLITICAL These refer to the magnitude of government intervention in the economy.   Most times the foreign policy of a country plays an important role in determining the trade regulations that could either lead to trade restrictions or trade incentives.   A company can be highly affected by specific regulations imposed by the government. ECONOMICAL Future operation of a company/organization is highly affected by economical factors. Also, the cost of imported and exported goods are highly affected by the changes in exchange rates in different regions. The expansion and growth of an organization are highly influenced by the economy since there is a change in cost of capital. (Yà ¼ksel, I. (2012). SOCIAL The macro-environment of the organization is formed by different social factors, cultural and demographic aspects of the Social factors include attributes in ones career, age distribution, growth rate, population, how individuals are conscious about their health and safety. A keen analysis of these factors helps one understand the PESTEL analysis and help organizations understand the dynamics of existing and the availability of potential markets and future customer needs. TECHNOLOGICAL With the speed at which technology is evolving and customers becoming more acquired to it, organizations have no option but to keep up with this pace.   New technology makes the old one obsolete and outdated. An organization/company that is not ready to embrace new technology is at a chance of lagging behind its competitors and losing its market value. LEGAL These are factors that affect the behavior of customers and the operation of businesses. Things which may be affected by legal factors are product transportation, profit margins, and viability of certain markets just to mention a few. These factors help in knowing if there are any dangers behind selling certain products like drugs and sharp objects and can also affect how a company stocks their inventory or interacts with the customer. Consumer law is used so as to protect consumers from companies that are involved in fraud and also preserve their rights when in the market. This affects business because they have to put aside resources so as to give detailed information about their products and services.   Employment law is also known as labor law, and it explains how companies’ employees should be treated. This also helps protect children from child labor and also it makes the firing of innocent employees a bit harder. SAMSUNG SWOT ANALYSIS Samsung Electronics Co. Limited is the consumer electronics subsidiary of the Samsung Group, based in Suwon, South Korea. Samsung is popularly known as the world’s largest manufacturer of mobile phones, smartphones such the highly popular and successful Galaxy as well as other electronic devices like Television sets, LCD panels home theaters, refrigerators and even cooking appliances. Having a great and undisputed manufacturing and marketing expertise, Samsung is regarded as the world’s second largest consumer electronics company the first being Apple,Inc. its American rival. STRENGTHS †¢Ã‚  Ã‚   It is the world’s most successful electronics manufacturer of television sets, liquid crystal display (LCD) panels, mobile phones and smartphones and other electronic appliances. †¢Ã‚  Ã‚  Ã‚   By use of its strategic marketing style Samsung is the world’s number one mobile phones seller with the world’s largest market share of 21.4% in 2015s second quarter. Apple comes second   with 13.9% †¢Ã‚  Ã‚  Ã‚   By use of its impressive research and design capabilities, Samsung has been able to create and roll out a payment app with similar capabilities to Apple Pay, in less than a year the Samsung Pay.   Also, the company has been able to incorporate many of the capabilities of both Apple phones and Google Android operating system to its mobile devices. †¢Ã‚  Ã‚  Ã‚   Samsung not only has strong manufacturing capabilities but also have undisputed marketing strategies that have led to the success of the company. †¢Ã‚  Ã‚  Ã‚   Samsung has been able to sustain long-standing relationships with retailers in the United States and Europe that have been able to provide a steady sales channel for its products through out the years. WEAKNESSES †¢Ã‚  Ã‚   It is quite clear that Samsung has not been able to match Apple Inc.’s marketing capabilities for smartphones. This is because   Its share of the U.S. smartphone market fell by 2.3% between 2014 and 2015 yet Apple’s share price grew by 34.9%. †¢Ã‚  Ã‚  Ã‚   Some Chinese competitors such as Huawei and Xiaomi are catching up to Samsung in the smartphone market. In the year 2014 and 2015 Huawei’s share grew by 48.1%, and Xiaomi’s share grew by 29.4%. †¢Ã‚  Ã‚  Ã‚   Samsungs dependence on customer electronics sales in markets that have limited resource for growth is dangerous. The company depends on these markets an example being the United States and Europe, for much of its revenue. †¢Ã‚  Ã‚  Ã‚   The public has not accepted the Android operating system in an equal manner like the tech community. This is because many consumers view Android as an inferior product to Apple’s IOS.   Samsung devices use the Google source application system and this is a weakness because it is not preferred by a majority of people.   †¢Ã‚  Ã‚  Ã‚   Apple products are viewed as more technology advanced and dependable on than Samsung products by a large number of consumers. †¢Ã‚  Ã‚   Samsung needs to improve its marketing efforts and standards, so as to be in the same level as Apple. OPPORTUNITIES †¢Ã‚  Ã‚  Ã‚   Samsung needs to grow its market for smartphones, tablets and other technological devices in developing regions where consumers are not familiar with PCs.   This is because in 2015 sales of tablets overtook sales of traditional personal computers. An example of these regions is Africa and India. †¢Ã‚  Ã‚  Ã‚   Samsung should seize the increased demand for tablet and smartphone-based solutions and market some of its products that are not known to many such as Samsung Pay †¢Ã‚  Ã‚  Ã‚   The company should venture into new technologies such as wearable tech †¢Ã‚  Ã‚  Ã‚   The growth of the middle class in the developing world will increase the market for consumer electronics †¢Ã‚  Ã‚  Ã‚   Sales channels such as Amazon.com can be used by Samsung to grow its online market THREATS: †¢Ã‚  Ã‚  Ã‚   Samsung has not been able to outdo Apple. This is because Apple has emerged as the dominant smartphone and tablet brand in some markets, such as the United States. †¢Ã‚  Ã‚  Ã‚   The growth of Apple’s reputation for quality, reliability, and sophistication is a threat to Samsung because it seems to be lagging behind. †¢Ã‚  Ã‚  Ã‚   Samsung is most popular for its Galaxy devices. We could even say that it depends on these devices. The problem is, the Google Android operating system, which these devices depend upon, is not as popular with average people as iOS that is in most other devices incuding Apple is. †¢Ã‚  Ã‚   Key markets for Samsung are North America and the United States.   The declining and stagnating of the middle-class incomes in these areas could reduce consumer buying power and therefore affect Samsungs sales. †¢Ã‚  Ã‚  Ã‚   Samsung is experiencing rivalry from Chinese manufacturers such as Huawei and Xiaomi. This is evident because the capital share of these companies rose and Samsung’s is falling. †¢Ã‚  Ã‚  Ã‚   If Apple decided to produce more consumer products like home appliances and cameras, Samsung could be greatly affected. Though Samsung has been able to maintain an impressive research, design and manufacturing capabilities, its marketing strategies are questionable. There is a need for the company to revisit and improve its smartphone marketing and design efforts so as to be able to maintain its market share in crucial arenas like the U.S. If the Samsung wants to maintain its position as an industry leader it needs to: 1. New capabilities like Samsung Pay 2.   learn to deal with aggressive Chinese competitors like Huawei and Xioami 3.Compete with Apple’s reputation. PESTLE ANALYSIS OF SAMSUNG INTRODUCTION Samsung is a global company that operates in the market for consumer appliances and gadgets. Samsung is owned by a South Korean family and has global aspirations to expand into newer markets. Since Samsung is not content with operating in some markets in the world, it wants to cover as many countries as possible. This analysis focuses on the external environmental factors that drive the Samsung’s strategy. POLITICAL A large number of markets where Samsung operates have a political environment that is conducive for business. This means that its operations run smoothly and though there might be some minor distractions to its operations in some of the foreign markets like India, Overall it can be concluded that Samsung is operating in markets where the political factors are not harmful. Samsung has faced significant political blows in its home country South Korea because of the country’s tensions with North Korea. Due to this instability, the company has had to take into account this political factor and also the threat of war in the Korean Peninsula. In areas where the political environment is unstable Samsung faces a lot of political pressure. This includes areas in many African and Latin American countries where the political environment is unstable and experiences frequent changes in the governing structures.This is not yet a major cause for worry for the company because it has factored the political instability into its strategic calculations. ECONOMICS Opening up of several markets in the developing world means that Samsung can expand in the global markets. This, therefore, means that economic factors are a critical consideration. The current global economic crisis has affected the purchasing power of customers forcing the company to seek profitable ventures in the emerging markets. The global environment in which   Samsung operates in has a lot of uncertainties and volatilities which means that the company has to keep on adjusting its strategies. Through expansion of Samsung into emerging and developing markets has made it possible for the company to adjust well to the tapering off of the consumer disposable incomes in the developed world. This is the main reason that Samsung has an aggressive push into the emerging markets with hopes that it shall recover all its lost businesses in the developed world. SOCIO-CULTURAL Samsung being a South Korean multinational owned by a family means that despite its global footprint it still operates from the core of a Korean company and culture. This means that among its global operations, adapting itself to local conditions is paramount. Since Samsung is a global company that has had to act locally, therefore adapting a global strategy makes it possible to be productive in emerging markets. Together with this, Samsung has had to tailor its products in markets it operates in so as to cater to their customers whose preference changes so fast.   It is important to note that Samsung operates in a market niche that is strongly influenced by the lifestyle preferences of consumers.   The fact that socio-cultural factors are different in each country; Samsung has had to reorient itself in each market accordingly. TECHNOLOGICAL Samsung is considered to be among the world’s leading innovative companies. Therefore, the company is at an advantage of controlling and making use of the power of technology and driving innovation for sustainable business. This has resulted into an obsessive mission by the company to outdo its rivals and competitors when it comes to technology and innovations. The companys main goal is to be the first to reach the produce devices that are preferred by customers and also be the first products of their kind in the market. LEGAL Due to Samsungs alleged imitation of the Apple’s iPad and iPhone it has had to face substantial penalties and law suits. This affected the company negatively on areas of public perception and consumer approval strategies. From Samsungs experience of having various lawsuits with its competitors, other technology driven companies should know that having an elaborate basis of a design or model is key rather than making a fast move so as to be able to present a product to the consumers that shall, in the end, ruin your reputation. ENVIRONMENTAL Samsung has to be on the lookout when making its products so as to be able to satisfy its customers. When doing this, it has to take into account its social and environmental responsibilities so as to make sure they are both ethical.   Therefore, this means that the company should ensure that it does not compromise on its staff wages or their working conditions for they are all involved in producing the final product. (Grade and Pestel) CONCLUSION As Samsung prepares to expand globally, it has to be sure of what is expected of it. Technology changes so fast and customer preference even faster. Therefore, with this analysis, Samsung has clear guidelines on what to expect in the global consumer landmine. REFERENCES GRADE, G. B. PESTEL Analysis Of The Energizer. Hill, T., & Westbrook, R. (1997). SWOT analysis: its time for a product recall.  Long range planning,  30(1), 46-52. Khan, U. A., Alam, M. N., & Alam, S. (2015). A Critical Analysis of Internal and External Environment of Apple Inc.  International Journal of Economics, Commerce and Management,  3(6), 955-961. Kim, M., & Park, J. (2011, February). Demand forecasting and strategies for the successfully deployment of the smart TV in Korea. In  Advanced Communication Technology (ICACT), 2011 13th International Conference on  (pp. 1475-1478). IEEE. King, R. K. (2004). Enhancing SWOT analysis using triz and the bipolar conflict graph: a case study on the Microsoft Corporation.  Proceedings of TRIZCON2004, 6th Annual Altshuller Institute. Yà ¼ksel, I. (2012). Developing a multi-criteria decision making model for PESTEL analysis.  International Journal of Business and Management,  7(24), 52-66.

The Biopharmaceuticals An Overview Biology Essay

The Biopharmaceuticals An Overview Biology Essay Biopharmaceuticals are defined as proteins and nucleic acids which are used for therapeutic purpose. These are high molecular weight substances prepared by biotechnological means and genetically engineered. Due to their complex structure and intricate molecular composition it is very difficult to characterize and formulate such products. Most of these products are derived from biological species and genetically engineered to produce a potent compound [1-3]. Humulin (biosynthetic recombinant human Insulin) was the first biopharmaceutical product developed by Genentech but licensed and marketed by Eli Lily and Company in 1982. In the modern era biopharmaceutical products have become a major facilitating reason of technological changes in health care sector, causing extraordinary benefits for patients, cost challenges for consumers, and profits for market shareholders.[4] Over the last decade biopharmaceutical market is the fastest growing segment in the pharmaceutical organizations. After post-recession period vigorous advancement has been seen in this area. It has been reported that approximately 40% of total pharmaceutical RD investment is occupied by biopharmaceutical products amongst which, monoclonal antibodies and product produced by recombinant DNA method are the most prevalent one.[5,6] Proteins with different amino acid sequences are the primary structure of such products. For determining the biological activity of a protein it is necessary to study its three-dimensional structure. The structure of protein is generally divided into four categories i.e. primary, secondary, tertiary and quaternary (fig. 1). The primary structure is the sequence of amino acid residues which folds and stabilized by the formation of hydrogen bonds with subsequent molecules in the polypeptide chain to produce an  ÃƒÅ½Ã‚ ± helix,  which is a spiral, rod-like st ructure, or a  ÃƒÅ½Ã‚ ² sheet,  a planar structure. This structure resembles to the secondary structure of proteins. The tertiary structure is a three-dimensional arrangement which gives an overall conformation of a polypeptide chain. Through hydrophobic interactions between the non-polar side chains and disulfide bonds, this tertiary structure is stabilized. A quaternary or multimeric protein contains two or more polypeptide chains, held together by non-covalent bonds.[7] fig 1. Structure of protein. Because of their unique physicochemical characteristic it is very hard and challenging to formulate biopharmaceuticals as products with therapeutic effects and storage characteristics. Meanwhile their formulation is in many ways different from conventional low-molecular drug formulation. Despite of such facts biopharmaceuticals gains lots of attention in the modern era of drug formulation. In the recent reviews it has been discussed that around 400 biotechnology-based medicinal and therapeutic agents are either registered or in the clinical trials are reviewed by the regulatory bodies. These agents are helpful in treating many life threatening diseases some of them are cancer, infectious diseases, autoimmune diseases, and AIDS/HIV. Some of the agents which are already in the market are monoclonal antibodies, recombinant hormones, cytokines, vaccines, recombinant blood factor, and therapeutic enzymes.[5] Discussion Biopharmaceutical market In 1970, discovery of recombinant DNA technology and monoclonal antibodies lead to initiate the development of biopharmaceutical industries. A substantial growth from $8 billion in 1992 to $149 billion in 2010 quenched the thirst of investors towards the biopharmaceutical industry. It is expected to reach $239 billion by 2015 with a growth rate of 9.9% annually. There are more than 400 Biotech drugs and vaccines are scrutinized under clinical stage, targeting more than 200 diseases. Meanwhile a large number of the population is now taking benefits from a number of biotechnological innovations like recombinant protein-based products e.g. monoclonal antibodies and some large molecule prescription drugs, which include hormones and vaccines. Table 1 illustrates some of the leading biopharmaceutical therapy classes by size worldwide in 2002. In 2008 approximately 39%, among the top 10 drugs sold globally, are biopharmaceuticals and is expected to rise to 79% of the top 10 drug sales by 20 14.[8] Table.1: Leading biopharmaceutical therapy classes by size worldwide 2002. Source: IMS MIDAS December 2002. However after the post recession period, fundings over health care and other sector is reduced which impede the growth rate of pharmaceutical industries up to significant extent. Although biopharmaceutical global sales thrive to attain high numbers in the global health sector. Biotechnological based products have generated $229 billion revenue in 2012 with an annual growth rate of 10.4%. Meanwhile the major focus of pharmaceutical organizations is on biopharmaceutical vs. Small molecule drugs which enables to allocate high funding towards this area. This may be due to very less generic biosimilar products available in the market. In year 2009 there are total 18 biopharmaceutical products are approved by US FDA which is higher than the previous years i.e. 11 in 2008 and 10 in 2007. In a report of Battelle Technology Partnership Practice, it was estimated that the overall impact of biopharmaceutical sector on the US economy is $917 billion. These companies are making alliances with oth er essential services such as computing and information, clinical trial and regulatory support services, technologies, manufacturing and equipment, and transportation and logistics providers.[9-11] Types of Biopharmaceuticals Cytokines Cytokines are a diverse group of non-antibody intercellular signalling regulatory proteins i.e. glycoprotein and low molecular weight peptides produced in very little amount inside the body. They function as a mediator for communication between various cells and induce certain response by binding to specific cell surface receptors which results in triggering various intracellular signal transduction mechanism. There are over 80 sub class of cytokines have been found. Some of these are categorized in table 2. They play an important role in coordinating embryonic development, cell growth and maturation, wound repair and healing, the immune response including acute phase reactions and septic shock, and new blood vessel formation. Cancer is among the major class of disease which is thoroughly scrutinized by the researchers with an emphasis on cytokines. However cytokines also play a vital role in mediating signalling response to systemic inflammation which tends to regulate specific neur onal network to induce sickness. Some animal studies reveal the role of cytokines in situations characterized by abnormal sleep, with emphasis on the pathogenesis of symptoms and consequences of OSAS (Obstructive sleep apnoea syndrome). Cytokines interact with specific cells via (1) intracrine, in which both cytokine and receptor remain within the cell (rare); (2) autocrine, where a cytokine acts on the receptors of the same cell it is produced; and (3) paracrine, where the cytokine from one cell type interacts with receptors on other cell types.[12-16] Table 2: categorization of cytokines. There are various cytokines products available in the market and some of them are reviewed under the clinical phase for example Interleukin-2 (IL-2) aldesleukin (Proleukin), for treating renal cell carcinoma is approved by FDA. IL-1 blocker, anakinra (Kineret) and rilonacept (Arcalyst) are used for the treatment of rheumatoid arthritis and cryopyrin-associated periodic syndromes respectively.[1] Enzymes Enzymes are complex molecules produced by living cells. They increase the rate of chemical reaction without even showing their own effect in the process and hence act as a catalyst in living organisms.[17] Because of their reaction specificity, catalytic efficiency and ability to operate under mild condition of temperature and hydrogen ion concentration they are preferred as a novel class of therapeutic agents. Despite of their therapeutic role enzyme endures significant importance as a replacement therapy in many genetic disorders. However there are some disadvantages as well associated with their use such as, their parental administration required extensive purification to remove contaminants. They are also very costly to prepare and due to their large molecular structure they have limited distribution in the body. As they are proteins hence when administered inside the body act as antigen to the host cell.[18,19] Enzymes are categorized under six major classes i.e transferases, lysases, hydrolases, isomerases, ligases, and oxidoreductases. The potential utility of enzyme as pharmaceutical was noted many decades ago. However most of the enzyme therapies are used to treat functional defects. Activase ® (alteplase; recombinant human tissue plasminogen activator), is the first recombinant enzyme drug which was approved by the Food and Drug Administration in 1987. Pulmozyme ® (Dornase alpha), a recombinant DNAse I that digests DNA in the mucous secretions in lungs, used to treat cystic fibrosis. Adagen ® (pegadamase bovine), is the first marketed product as enzyme therapy for the treatment of SCID (severe combined immunodeficiency disease).[20] Hormones Hormone is characterized as an important group of regulatory molecule which is synthesized in an organ or in tissue and then secreted into circulatory system where it affects respective organs whose cell bears an appropriate receptors. They are chemical messengers either small or a large macromolecule and are fairly defined as endocrine hormones. Approximately all endocrine hormones possess therapeutic importance and hence subsequently used by the researchers e.g. insulin(Insugen ®, Humulin ®, Novolin ®), human growth hormone (Ascellacrin ®, Crescormon ®), glucagon, and the gonadotrophins.[1] Antibodies: Antibodies or immunoglobulin are proteins produced, as an immune response, through white blood cells when a foreign particle or antigen intrudes inside the body. There are five classes of immunoglobulin IgE, IgM, IgG, IgD, and IgA. Amongst them IgG is the most common as a biopharmaceutical agents. A more specified term i.e. monoclonal antibodies (mAb  or  moAb) are the novel class compounds that are first developed in mid 1970s by kohler and Milstein, who successfully fused immortal cells with antibody- producing B lymphocytes. This fusion results in a hybrid which is stable, cancerous, antibody- producing cells. These are referred as hybridoma cells which unveil great source of monoclonal antibody. mAb identify antigens on a particular foreign body very specifically. mAbs are categorized under four groups according to their source: murine (derived solely from mice), chimeric (mixture of murine and human sequences), humanised (contain over 90% human sequences) and fully human.[8, 17] In 1986, Murobmonab (OKT3), a murine antibody, is the first monoclonal antibody tested as a therapeutic in humans. However it fails to produce a substantial response in the transplantation rejection patients because of production of anti-murine antibody.[20] Monoclonal antibodies are the fastest growing therapeutic class in the field of biopharmaceutical market. The market of monoclonal antibodies crosses the mark of $30 billion in 2011. Infliximab (Remicade) is the top selling monoclonal antibody in 2002 which was developed by Centocor and is marketed by Centocor and Schering-Plough for the treatment of rheumatoid arthritis (RA) and Crohns disease. Rituximab (Rituxan), developed by Genentech and IDEC and marketed by Genentech, IDEC and Roche, for the treatment of non-Hodgkins lymphoma, is the second largest selling monoclonal antibody.[21] Vaccines: Vaccines are antigenic proteins which are either partial or modified form of bacteria, viruses and toxins which causes certain diseases against which vaccine protects. The antigenic property of vaccines is altered from its original form by certain processes such as utilizing attenuated viruses, inactivated viruses, part of a virus or bacteria and toxin produced by bacteria; hence they lack ability to cause disease although, endures ability to produce an immune response.[22] Vaccines are the only known prophylactic approach which are commonly available to cure many infective diseases. Vaccines cover the global market share of $ 3 billion annually. Government health agencies run different immunization programs which alleviate the risk of many infective disorders. However, there are approximately 15 million people die every year from certain infectious diseases that can be cured by vaccination process. Pharmaceutical and biopharmaceutical industries seek great potential in this area but the use is limited because of their high production cost, delivery and distribution problems. Vaccines may contain animal derived products such as Bovine serum albumin or fetal calf serum or human derived product for example using cell lines of human tissues. However in recent years transgenic and recombinant plants are also utilized for the production of vaccines.[12,23,24] There are different vaccines available in the market for many infectious diseases such as poliomyelitis, cholera, diphtheria, tetanus, hepatitis B, hepatitis A, measles, meningitis etc. For hepatitis B virus some examples are Baraclude (Entecavir ®), Adefovir dipivoxil (Hepsera ®), Lamivudine (Epivir ®-HBV, 3TC), Alfa Interferon (Intron ® A, Infergen ®, Roferon ®).[1,25] Antisense drugs: Antisense compounds are non-coding strand of messenger RNA(mRNA), which hybridize with mRNA and inactivates the ability of genes to produce the protein for which it holds the recipe.[26] They do not alter human gene causing variation in human genetic information. It was first developed in 1978 using a string of DNA nucleotide which binds with messenger RNA and block its function. These drugs are designed to treat a wide range of diseases such inflammatory, infectious, cancer and cardiovascular diseases. Fomiversen was the first antisense drug approved in 1998 for the treatment of cytomegalovirus retinits in AIDS patients. These are categorized under three sub-classes i.e. antisense oligonucleotides(ASONs), ribozymes and RNA interference(RNAi). Affinitak, manufactured by ISIS pharmaceuticals and Eli Lilly, is used for the treatment of non-small-cell lung carcinoma(NSCLC). There are certain antisense compound are under review by health agencies for their therapeutic efficacy towards ma ny anomalies[27,28] Peptide therapeutics: Peptides are polymers having one or two amino acids linked with amides and are chemically synthesized by using liquid phase or solid phase synthesis. Their chemical synthesis is preferred over biosynthetic approach because it facilitates the conjugation or incorporation of small molecules and non-natural amino acids. This approach reveals the potential of such molecules as cytotoxic agents for antitumor therapy. Peptides with non-natural opens up the possibility for greater chemical diversity, analogous to small-molecule medicinal chemistry approaches for developing high-af ¬Ã‚ nity, highspeci ¬Ã‚ city molecular recognition. Cationic antimicrobial peptides (CAMPs) and peptidoglycan recognition proteins (PGRPs)are developed from the effectors of innate immune response in eukaryotes during their defense mechanism. However there are not many products of peptides found in the market but researchers are trying to develop some therapeutic peptides and proteins with significant effect towards certain diseases. Nesiritide (Natrecor, Noratak) is produced by Johnson Johnson2001, Teriparatide (Forteo) is developed and marketed by Lily in 2002 Enfuvirtide (Fuzeon) is manufactured by Trimeris 2003.[29-31] Challenges associated with biopharmaceutical products: Biopharmaceutical products such as monoclonal antibodies, vaccines, certain hormones, and cell therapies are rewarded as some of the most promising innovation in the field of medicine and health. However there are certain risk and challenges associated with such products which hamper their performance. One of the major challenges is the purification of proteins although it can be achieved by various processes but still purification of such compound is very critical hence requires a lot of attention during manufacturing. Next generation pharmaceutical.[32] However the whole process is carried out under two phases i.e. upstream and downstream regulation. Immunogenicity associated with some of these proteins is also a major concern for biopharmaceutical agents. A repeated injection of human protein may affect the immune tolerance towards self- antigen, leading to humoral response.[33]   Biopharmaceutical products require greater attention, process level as well as monitory level, in the development phase of the drug discovery process it requires approximately $200 million to develop a biopharmaceutical product hence the risk associated with their failure during development stage is increased. Apart from purification and immunogenicity some other issues also make some impact during their development such as government regulations which influence the cost of such products. As discussed earlier it takes a large amount of money to develop such agents hence companies also compensate their development cost and earn profits from their products, ones marketed, which exponentially increases the cost of the drugs. Last and one of the most important risk associated with such products is the introduction of biosimilar products. Biopharmaceutical market is growing very fast, the initial compounds of the first generation are now coming to an end. The expiry of the patents opens the market for generic products which not only influence the established market of some very popular brands, it also forms a milieu of competition to sell the products at cheaper rates which is compensated by their quality.[34] Conclusion Biopharmaceutical products are one amongst the novel class of therapeutic compounds. These are medical agents obtained from biological sources and some special one are manufactured by biotechnological means. They are cellular products, therapeutic proteins, vaccines, gene therapy products and plasma blood product derivatives. Erythropoietins, insulins, and monoclonal antibodies, are some of the leading biopharmaceutical products available in the market hence biopharmaceutical companies are now focusing on their use in long-term conditions such as cardiovascular disease, diabetes and asthma. The blockbuster sales of some existing biopharmaceutical products accompanied by the tremendous innovation and a plethora of pipeline products demonstrate the vigorous growth in the biopharmaceutical market in upcoming years. This significant growth is supported by some of the key segments of the field like monoclonal antibody and vaccines. In addition approaches like gene therapy and peptide ther apeutics holds enormous potential for some life threatening anomalies and the combined approach of proteomics, genomics and biotechnology is predicted to empower the most part of the healthcare sector in the upcoming days.

Managing People :: essays research papers

Managing People Task One Discuss how you would approach the task initially. I would initially approach the task slowly and carefully. I would carefully read the brief for the task, underlining or highlighting the important parts of the brief that concern the jobs and roles performed by Mrs. Pane. I would also try to gather information about the tasks and roles she performed. The brief describes how Mrs. Pane performed the jobs of a Receptionist/Telephonist and also that of a personal assistant. After gathering information on these jobs I would then try to break down each different aspect of the job i.e. Receptionist- fluent in typing. After I have broke down each job aspect I could then start to write the person specification element of the assignment. To write the person specification properly I would have to decide what the aspects of the job were desirable and what aspects were essential to the job. To successfully produce my own job advertisement I would need to look at job advertisements that are already in local newspapers and local job papers. I believe that the advertisement needs to contain all relevant information on the job vacancy but must also give a brief history of the company and maybe also an indication of how the company wants to grow or expand in the future. The advert could also include the mission statement of the company. Task four I would approach by considering what companies look for in potential employees i.e. personal qualities not just purely on qualifications. All the tasks have to be looked at carefully to make sure that no law or legislation is broken. Task Four Outline how you would select a candidate from the 27 applicants, including the main elements of documentation. Before selecting a candidate, the applications would have to go through many different filtering and screening processes. I would have the applicants send their c.v’s to the company because a c.v can contain a lot more information about someone than an application form because of its limited questions. One of the first filters in my selection would be age. I believe that someone under thirty would not have the experience or the relevant knowledge to perform the job of personal assistant and receptionist. However I also believe that someone over fifty would struggle to keep on top of such a heavy workload. I believe that employing someone over fifty does not show that you are thinking long term about the future success of a company.

Essay --

Anxiety disorders are the 2nd most diagnosed mental illness in the United States. Anxiety comes from the â€Å"fight or flight† physiological response in ones body. The fear a person experiences is an intense emotional alarm accompanied by a surge of energy in the autonomic nervous system. The surge is what motivates us to flee from danger, cueing the â€Å"flight† response. However, some anxiety is good for us in moderate amounts. Most people perform better when we are a little anxious (Yerkes & Dodson, 1908). Anxiety can improve test performance or make you more energetic and charming on a date. It improves, social, physical, and intellectual performance. In fact little would get done if we didn’t have any anxiety. However anxiety can be negative as well. The most common symptoms are looking worried and anxious or fidgeting. That is pretty normal for most people. These symptoms are a physiological response that starts in the brain. It elevates the heart rate and creates muscle tension. Most of the research has been done with animals. Animals seem to experience anxiety in a similar way to ...

Computer Protection and Maintainance Report Essay

I hope you have received the machine in good working order. Now that you have the machines, there are several pieces of ‘Utility Software’ that should be installed on your machine in order to assist with the smooth running and protection of the machine. There are four main categories for this Protection Virus To protect the computer from malicious software that can break the machine. Firewall To prevent hackers and malicious programs making internet connections for bad purposes. Clean-up tools These provide no protection; however they remove unnecessary files and registry entries. They can also remove spy ware sometimes. Disk Formatting These tools are useful only when formatting the disk drive. This doesn’t normally need to be done, unless there is a severe problem with the OS. There are several programs that fit in each category, and there are advantages and disadvantages to each application. These can include Cost, Resource Footprint and usability. Sometimes the free utilities can also be the best ones. All vary, some are awful and some are brilliant. Hopefully this email should outline which ones are best for the system, and which ones I would recommend. Virus Protection Virus Protection scanners, go through three places to find virii. HDD – Looks at every file on the disc. Memory – Scans the currently running memory to see if a virus is running now Behaviour – Scans both the memory and hard drive for suspicious well known behaviour and – patterns that suggest malicious software Software Suggestions GRISOFT – AVG 1. Completely Free 10/10 2. Anti-Virus & Anti-Spy ware Protection 8/10 3. Slow Virus Search -3/10 4. Simple Interface 5/10 5. Medium Power Footprint 5/10 Total Score = 25/50 Very popular solution, highly recommended- will DEFINITELY PROTECT the machine from viruses and spy ware. But is a drain on resources and takes a long time to scan for threats. NOD32 Anti-Virus 1. Costs per year à ¯Ã‚ ¿Ã‚ ½29.95 (for updates + strong protection) 5/10 2. Antivirus Only 7/10 3. Regular Virii search speed 5/10 4. Tricky interface – set and forget style. 3/10 5. LOW power footprint 10/10 Total Score 30/50 Not so well known but very powerful anti virus system. Will DEFINITELY protect the machine from virii. Will not drain system resources too much and does quick scanning. The only real issues are the lack of Spy ware protection and the expensive price plans. Firewall Protection Firewalls control inbound and outbound traffic on either a network or an individual machine. This can be achieved by either software or hardware. Software is best for your situation. Software Suggestions Windows Firewall 1. Costs Nothing (other than buying windows [which is pre installed]) 10/10 2. Inbound Protection Only 4/10 3. Minimal Interface- set and forget style (with occasional alerts) 4/10 4. LOW power foot print 9/10 Total Score 27/40 The windows firewall is an effective and quite protective measure for securing a windows machine although it only has INBOUND protection, so if a virus is transmitting bad data, the WINDOWS firewall will not protect you. ZoneAlarm Firewall 1. The Free Version is FREE (although a pro version can be bought) 10/10 2. Inbound + Outbound Protection Alerts for each program 9/10 3. Complicated, but comprehensive interface (STOP BUTTON) 6/10 4. HIGH power footprint 4/10 Total Score 29/40 Zone Alarm- Firewall Specialists for a long time. Will protect both ways and will request permissions for every program it does not recognise. I highly recommend this software as it provides strong and reliable protection. Clean Up Tools Registry Doctor 1. This software costs money (à ¯Ã‚ ¿Ã‚ ½17.50) 3/10 2. This software fixes registry errors, backs up the system, and adjusts the registry for speed. 7/10 (the adjusting could be dangerous) 3. Power hungry – will take a lot of resources when operational. 4/10 4. Click and GO! Interface, although the system is complicated when It comes to advanced settings. 5/10 Total Score 19/40 Registry doctor – A often occurrence, simply because of the constant advertising everywhere. This software is a suitable enough solution for most people however I believe it has spy ware built into it, and would not recommend it. Quicksys RegDefrag 1. This software is freeware 10/10 2. This software is a registry defragmenter- it will only optimise it. 4/10 3. Will take little resources, runs in the background (like the vista defrag)6/10 4. Set and Forget interface, no real options and hides during operation 8/10 Total Score 28/40 Quicksys RegDefrag is a simple set and forget registry defragmenter and streamliner. I believe this is the better option, as it will pick up redundant keys as it goes however a lack of options somewhat limits this software. Disk Formatting Darik’s Boot and Nuke (â€Å"DBAN†) 1. This software is Free 10/10 2. This software will overwrite the Hard Drive with ZEROS however many times you ask it to. 8/10 3. The computer is busy during the Disk Format (low level physical format)3/10 4. Set and forget – it can take sometime. Limited options 5/10 Total Score 26/40 DBAN- it’s a popular and useful tool. It simply erases your hard drive at a low level. It is loud, and you cannot use your OS at the same time- It is a simple FREE, but has limited options. Windows formatting tool 1. This software is free with windows. 8/10 2. The software will perform a high level software format. 5/10 3. You can only format a drive that windows isn’t using. 3/10 4. You can format a drive to any FS type provided the disk supports it. 7/10 Total Score 23/40 Windows formatting tool isn’t very powerful, is noisy if formatting a hard drive, and is very slow. Although if doing a quick format it will be a bit quicker. You can use your OS, but incredibly slowly. Conclusion Based on the above statistics I would recommend this software: * NOD32 Anti Virus * Zone-Alarm PRO Firewall * QuickSys Reg De-Frag * DBAN – Boot and Nuke I have done my best to always provide a free alternative, but it will not always be the best option. You should make your own decision based, on the facts above, and the software manufacturer’s website. I put my faith into EVERY product I have mentioned. I hope this email will help you to decide what you need to use to make the computer you will shortly be receiving, the best machine for miles around!.

I Have No Idea Essay

* 1. How does the author define â€Å"cell yell† (paragraph 2)? What changes in society since the 1950s does the author suggest account for the way people use cell phones today? -The author defines â€Å"cell yell† as a bad behavior from a human talking on the phone too loud, in a way that is including stranger into his private conversation. In the 1950’s, people were used to have their conversations inside an enclosed phone booth where no one could hear their conversation. These phone booths where at public places. Nowadays people don’t care about having privacy when they are talking on the phone. * 2. How does mobile phone design contribute to bad cell phone manners? -Mobile design tend to make us feel that the other person on the phone can’t hear us clearly or vise versa because of the phone’s size and how close the mouthpiece is to our mouth. What part does the cell phone user’s sense of self-importance play? -I believe that the part that cell phone user’s sense of self-importance play is for the other person to who we are talking to can listen to us clearly. * 3. Eavesdroppers on cell phone conversations experience various reactions, both positive and negative. According to the author, what are some of these reactions and how do people listening against their will handle their strong feelings? -Some people still talk on the phone privately, others don’t. Some people use text messages to express their feeling and not having to listen to the person’s disappointed voice. Some people prefer to receive a bad new via text message. * 4. Based on the author’s examples, what are the rude cell behaviors that bother people the most? What behaviors bother you the most? You might wish to share with the class a humorous or outrageous illustration of bad cell manners that you have encountered. -The rude behavior that bothers people the most is when people are talking too loud. The behavior that bothers me the most is when I’m chating with someone and that person is using his phone instead of putting it away to bond with me. I honestly hate when people do that. WRITING ASSIGNMENTS * 1. Write an essay in which you argue for or against having a â€Å"designated outcast zone† for cell talkers in restaurants, theaters, or other places—the way many establishments now isolate smokers. Develop your thesis with two or three clear supporting points. -People that talk on the phone on quite places. People that text instead of paying attention to what really matters. * 2. Is the rudeness of cell phone users just a symptom of a society that has become less considerate and more self-centered? With a group of classmates, brainstorm other possible â€Å"symptoms† of this trend. Some ideas might include rude clerks and customers, aggressive drivers, or the dying art of thank-you notes. Then select one of these and write an essay in which you suggest ways to reverse the trend. -Yes I believe it is. Aggressive drivers. People nowadays don’t care about other people anymore. For example in Miami, at least one or two hit-and-run happens every week. People scream from car to car. People shot other people for beeping. 3. E-mail and texting are just two other technologies that some people use inconsiderately or even abusively. For instance, some people forward jokes many times a day, and others text during meetings or dates. Write an essay in which you suggest rules of web etiquette for one technology. You may wish to look up â€Å"netiquette†Ã¢â‚¬â€the word for rules to govern online behavior. -Texting. There is people that text 24/7. They can’t live without texting on the phone. Something else that’s being ruining us are smart phones that offer us social network for us to use at anytime, this is overwhelming. People pay more attention to their phone nowadays because of those social networks.